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KMID : 0367419940370010019
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Journal of Korean Pediatric Society
1994 Volume.37 No. 1 p.19 ~ p.25
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Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements
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강은식
박정혜/최혜진/정종성/최규철
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Abstract
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Creatine kinase (CK) isoenzyme are considered as a specific tissus injury marker. Brain type isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from periphera blood at six to ten
hours
after birth.
There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well correlated to the degree of hypoxic ischemic encephalopathy. Seventeen infants died in newborn period had higher CK-BB activity than 60
infants
who survived at discharge.
We conculuded that early CK-BB determination can be used as and indicator of neonatal brain damage and neonatal death. It is warranded to do long-term follow-up for evaluation of neurologic outcome.
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KEYWORD
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